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Tianeptine sodium salt cas 30123-17-2 

  产品分类 : 化學->藥品->醫藥

     
Tianeptine sodium salt cas 30123-17-2
         

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  产品描述
   
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Chemical Name: Tianeptine sodium salt
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TIANEPTINE SODIUM
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TIANEPTINE SODIUM SALT
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sodium
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S-1574
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Stablon
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Molecular Formula: C21H24ClN2NaO4S
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Formula Weight: 458.93
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CAS No.: 30123-17-2
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<img src="http://i.bosscdn.com/product/f4/fc/52/68b8b48b0a3c5d51c83d5e9d85.gif" title="30123-17-2" alt="30123-17-2" />
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Tianeptine is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
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Tianeptine (Stablon) is a novel antidepressant and anxiolytic used to treat depression in Europe. Tianeptine binds mu-opioid receptors in the brain which may give it an advantage over typical antidepressants. Structurally, Tianeptine is a tricyclic antidepressant (TCA), though it`s mechanism of action and side effect profile is unlike other TCAs.
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Tianeptine is an atypical antidepressant with diverse actions, most notably on the glutamatergic system.1,2 It attenuates glutamate release and modulates the function of the AMPA receptor.2,3 Tianeptine also acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641 nM for human and mouse receptors, respectively).4 It is as effective as fluoxetine (Item No. 14418) in the management of post-traumatic stress disorder
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</p>pharmachemm.com

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